Chen JL et al., Dunbar PR. (2005). Structural and kinetic basis for heightened immunogenicity of T cell vaccines. J Exp Med. 201 (8): 1243.

Novel Peptide Chemistry

Lu BL, Williams GM, Verdon DJ, Dunbar PR, Brimble MA. (2019). Synthesis and evaluation of novel TLR2 agonists as potential adjuvants for cancer vaccines. J Med Chem.

Kowalczyk R, Harris PWR, Williams GM, Yang SH, Brimble MA. (2017). Peptide lipidation - a synthetic strategy to afford peptide based therapeutics. Adv Exp Med Biol. 1030: 185-227.

Yang SH, Harris PWR, Williams GM, Brimble MA. (2016). Lipidation of cysteine or cysteine-containing peptides using the thiol-ene reaction (CLipPA). Eur J Org Chem. 2608-2616.

Wright TH et al., Dunbar PR, Brimble MA. (2013). Direct peptide lipidation through thiol-ene coupling enables rapid synthesis and evaluation of self-adjuvanting vaccine candidates. Angew Chem Int Ed. 52(4): 10616-10619.

NY-ESO-1 Peptide Selection 

Gasser O et al., Brimble MA, Dunbar RP. (2018) A phase I vaccination study with dendritic cells loaded with NY-ESO-1 and alpha-galactosylceramide: induction of polyfunctional T cells in high-risk melanoma patients. Cancer Immunol Immunother. 67: 285-298.

Chen JL et al., Dunbar PR. (2000). Identification of NY-ESO-1 peptide analogues capable of improved stimulation of tumor-reactive CTL. J Immunol. 165(2): 948-955.

Jager E et al., Dunbar PR. (2000). Monitoring CD8 T cell responses to NY-ESO-1: correlation of humoral and cellular immune responses. PNAS. 97(9): 4760-4765.